N-Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate

Names

[ Name ]:
N-Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate

[Synonym ]:
MFCD00009634
1-[(4-{[(2,5-Dioxopyrrolidin-1-yl)oxy]carbonyl}cyclohexyl)methyl]-1H-pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 1-((4-(((2,5-dioxo-1-pyrrolidinyl)oxy)carbonyl)cyclohexyl)methyl)-
N-Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate
1-[(4-{[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl}cyclohexyl)methyl]-1H-pyrrole-2,5-dione
1H-pyrrole-2,5-dione, 1-[[4-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]cyclohexyl]methyl]-
N-Succinimidyl 4-(Maleimidomethyl)cyclohexane-1-carboxylate

Biological Activity

[Description]:

SMCC is a protein crosslinker. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Guo Y, et al. Potent antigen-specific immune response induced by infusion of spleen cells coupled with succinimidyl-4-(N-maleimidomethyl cyclohexane)-1-carboxylate (SMCC) conjugated antigens. Int Immunopharmacol. 2016 Feb;31:158-68.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
501.7±42.0 °C at 760 mmHg

[ Melting Point ]:
180-182 °C(lit.)

[ Molecular Formula ]:
C₁₆H₁₈N₂O₆

[ Molecular Weight ]:
334.324

[ Flash Point ]:
257.2±27.9 °C

[ Exact Mass ]:
334.116486

[ PSA ]:
101.06000

[ LogP ]:
-0.39

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.598

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
chloroform: 50 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2925190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

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J. Immunol. Res. 2015 , 561814, (2015)

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Solid formulations by a nanocrystal approach: critical process parameters regarding scale-ability of nanocrystals for tableting applications.

Int. J. Pharm. 485 , 77-86, (2015)

Nanocrystallization is among the foremost drug delivery platform approaches for the commercial development of poorly soluble drugs. There exists an urge to enable a universal shift of the production o...

An NIR-triggered and thermally responsive drug delivery platform through DNA/copper sulfide gates.

Nanoscale 7 , 12614-24, (2015)

Nanomaterials for effective drug delivery require zero pre-release and on-demand release of therapeutic drugs. In this work we demonstrate a novel drug delivery system composed of a mesoporous silica ...

Related Compounds

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