Schisantherin D

Names

[ Name ]:
Schisantherin D

[Synonym ]:
schizantherin D

Biological Activity

[Description]:

Schisantherin D is a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera. Schisantherin D shows anti-HIV replication activities with an EC50 of 0.5 μg/mL. Schisantherin D inhibits endothelin receptor B (ETBR) and has hepatoprotective effects[1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

[Target]

EC50: 0.5 μg/mL (HIV)[1]

[References]

[1]. D F Chen, et al. Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior. J Nat Prod. 1996 Nov;59(11):1066-8.

[2]. Jin-Biao Xu, et al. Lignans from Schisandra chinensis ameliorate alcohol and CCl 4-induced long-term liver injury and reduce hepatocellular degeneration via blocking ETBR. J Ethnopharmacol. 2020 Aug 10;258:112813.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₂₈O₉

[ Molecular Weight ]:
520.52700

[ Exact Mass ]:
520.17300

[ PSA ]:
101.91000

[ LogP ]:
4.66950

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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