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Sophocarpine

Names

[ CAS No. ]:
6483-15-4

[ Name ]:
Sophocarpine

[Synonym ]:
1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, 2,3,6,7,7a,8,13,13a,13b,13c-decahydro-, (7aS,13aR,13bR,13cS)-
Sophocarpine
Matridine-13-ene-15-one
Matridin-15-one, 13,14-didehydro-
Matridin-15-one, 13,14-didehydro- (9CI)
13,14-Didehydromatridin-15-one

Biological Activity

[Description]:

Sophocarpine is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy, activation of cell apoptosis and down-regulation of cell survival PI3K/AKT signaling pathway. Sophocarpine has been demonstrated to have anti-tumor activity in various cancer cells, including hepatocellular carcinoma, prostate cancer and colorectal cancer[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Signaling Pathways >> Autophagy >> Autophagy
Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Research Areas >> Inflammation/Immunology

[Target]

PI3K

Akt


[References]

[1]. Huang Y, et al. Sophocarpine inhibits the growth of gastric cancer cells via autophagy and apoptosis. Front Biosci (Landmark Ed). 2019 Mar 1;24:616-627.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
425.4±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H22N2O

[ Molecular Weight ]:
246.348

[ Flash Point ]:
194.0±21.1 °C

[ Exact Mass ]:
246.173218

[ PSA ]:
23.55000

[ LogP ]:
1.37

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.603

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds