Tetrahydropapaverine hydrochloride

Names

[ Name ]:
Tetrahydropapaverine hydrochloride

[Synonym ]:
EINECS 229-213-9
1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (1:1)
Papaverine, 1,2,3,4-tetrahydro-, hydrochloride
MFCD00035267
Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-, hydrochloride (1:1)

Biological Activity

[Description]:

Tetrahydropapaverine hydrochloride is one of the Tetrahydroisoquinolines. Tetrahydropapaverine hydrochloride has neurotoxic effects on dopamine neurons[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Koshimura I, et al. Dimethoxyphenylethylamine and tetrahydropapaverine are toxic to the nigrostriatal system. Brain Res. 1997 Oct 31;773(1-2):108-16.

[2]. Kim EI, et al. Inhibitory effects of tetrahydropapaverine on serotonin biosynthesis in murine mastocytoma P815 cells. Life Sci. 2004 Sep 3;75(16):1949-57.

Chemical & Physical Properties

[ Density]:
1.12g/cm3

[ Boiling Point ]:
475.8ºC at 760 mmHg

[ Melting Point ]:
213-215ºC

[ Molecular Formula ]:
C₂₀H₂₆ClNO₄

[ Molecular Weight ]:
379.878

[ Flash Point ]:
202.7ºC

[ Exact Mass ]:
379.155029

[ PSA ]:
53.53000

[ LogP ]:
0.69750

[ Index of Refraction ]:
1.549

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NX5070700

CHEMICAL NAME :: Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-veratryl-, hydrochloride

CAS REGISTRY NUMBER :: 6429-04-5

LAST UPDATED :: 198310

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H25-N-O4.Cl-H

MOLECULAR WEIGHT :: 379.92

WISWESSER LINE NOTATION :: T66 CMT&J B1R CO1 DO1& HO1 IO1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 149,200,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 149,200,1964

Safety Information

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
22

[ Safety Phrases ]:
36

[ HS Code ]:
2939190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%