MEL24

Names

[ CAS No. ]:
642072-48-8

[ Name ]:
MEL24

Biological Activity

[Description]:

MEL24 is an Mdm2 E3 ligase inhibitor that reduces cell survival and increases sensitivity to DNA damaging agents in a p53-dependent manner for in vitro antitumor studies[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

MEL24 作用于 293T 细胞，ED50 值为 9.2 μM[1]。 MEL24（15 μM，6 小时）增加 Mdm2、p53 和 MdmX 的水平并激活 p53，抑制 HCT116 细胞（p53 野生型）中内源性 MdmX 的降解[1]。

[References]

[1]. Ariel G Herman, et al. Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay. Cancer Discov. 2011 Sep;1(4):312-25.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₈N₄O₃

[ Molecular Weight ]:
326.35

Related Compounds

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