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akuammigine

Names

[ CAS No. ]:
642-17-1

[ Name ]:
akuammigine

[Synonym ]:
4-Acetoresorcinol
Methyl (3β,19α,20α)-19-methyl-16,17-didehydro-18-oxayohimban-16-carboxylate
2',4'-dihydroxyacetophenone
4-ACETYLRESORCINOL
Resoacetophenone
RESACETOPHENONE
akuammigine
Oxayohimban-16-carboxylic acid, 16,17-didehydro-19-methyl-, methyl ester, (3β,19α,20α)-
b-Resacetophenone
HyMechroMone
reserpiline

Biological Activity

[Description]:

Akuammigine is an alkaloid that can be found in hook-bearing branch of Uncariarhynchophylla. Akuammigine is a is a very weak antagonist at pre- and postsynaptic α-adrenoceptor of the rat vas deferens[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Research Areas >> Neurological Disease

[References]

[1]. Yang W, et, al. Almitrine-Raubasine combination for dementia. Cochrane Database Syst Rev. 2011 Mar 16;(3):CD008068.  

[2]. Qi W, et, al. Alkaloids from the hook-bearing branch of Uncariarhynchophylla and their neuroprotective effects against glutamate-induced HT22 cell death. J Asian Nat Prod Res. 2014;16(8):876-83.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
524.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H24N2O3

[ Molecular Weight ]:
352.43

[ Flash Point ]:
270.7±30.1 °C

[ Exact Mass ]:
352.178680

[ PSA ]:
54.56000

[ LogP ]:
2.88

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.656

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds