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Sennidin A

Names

[ CAS No. ]:
641-12-3

[ Name ]:
Sennidin A

[Synonym ]:
SENECIONINE(SH)
1',1,8',8-Tetrahydroxy-10,10'-dihydroanthrone-3,3'-dicarboxylic acid
EINECS 211-371-5
dihydroxydianthrone
(+)-4,5,4',5'-tetrahydroxy-10,10'-dioxo-9,10,9',10'-tetrahydro-[9,9']bianthryl-2,2'-dicarboxylic acid
4,4',5,5'-Tetrahydroxy-10,10'-dioxo-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid
(R*,R*)-(+)-9,9',10,10'-Tetrahydro-4,4',5,5'-tetrahydroxy-10,10'-dioxo(9,9'-bianthracene)-2,2'-dicarboxylic acid
[9,9'-Bianthracene]-2,2'-dicarboxylic acid, 9,9',10,10'-tetrahydro-4,4',5,5'-tetrahydroxy-10,10'-dioxo-
Sennidin A
(+)-4,5,4',5'-Tetrahydroxy-10,10'-dioxo-9,10,9',10'-tetrahydro-[9,9']bianthryl-2,2'-dicarbonsaeure
(+)-4.5.4'.5'-Tetrahydroxy-10.10'-dioxo-9.10.9'.10'-tetrahydro-[9.9']bianthryl-dicarbonsaeure-(2.2')

Biological Activity

[Description]:

Sennidin A, isolated from the leaves of Cassia angustifolia, inhibits HCV NS3 helicase, with an IC50 of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Sennidin A stimulates the glucose incorporation[1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HCV
Research Areas >> Infection
Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[References]

[1]. Furuta A, et al. Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase. Int J Mol Sci. 2015 Aug 7;16(8):18439-53.

[2]. Daigo Abe, et al. Sennidin stimulates glucose incorporation in rat adipocytes. Life Sciences. 2006.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
801.8±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C30H18O10

[ Molecular Weight ]:
538.458

[ Flash Point ]:
452.6±30.8 °C

[ Exact Mass ]:
538.090027

[ PSA ]:
189.66000

[ LogP ]:
8.24

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.806

[ Storage condition ]:
2-8℃

Safety Information

[ Risk Phrases ]:
22

[ Safety Phrases ]:
22-45

Related Compounds