LSTc

Names

[ CAS No. ]:
64003-55-0

[ Name ]:
LSTc

[Synonym ]:
N-ACETYLNEURAMIN-LACTO-N-NEO-TETRAOSE C SODIUM SALT
LS-Tetrasaccharide c sodium salt
LS-Tetrasaccharide c,Sodium Salt,Human Milk
4]-GLC SODIUM SALT
SIALYLLACTO-N-NEOTETRAOSE-C
N-acetylneuraminyl-lacto-N-neo-tetraose C sodium
LST C SODIUM SALT

Biological Activity

[Description]:

LSTc (LS-tetrasaccharide c) is a human lactooligosaccharide presents on glycoproteins and glycolipids. LSTc is also a specific human JC polyomavirus (JCV) recognition motif. LSTc has good potential for the study of progressive multifocal leukoencephalopathy (PML)[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Infection
Signaling Pathways >> Others >> Others

[In Vitro]

LSTc specifically engaged by JCV and inhibits JCV infection in SVG-A cells[1]. Cell Viability Assay[1] Cell Line: SVG-A cells Concentration: 5 mM (pretreat LSTc with JCV, then JCV-LST complexes are added to cells) Incubation Time: 1 h Result: Inhibited JCV infection.

[References]

[1]. Neu U, et al. Structure-function analysis of the human JC polyomavirus establishes the LSTc pentasaccharide as a functional receptor motif. Cell Host Microbe. 2010 Oct 21;8(4):309-19.  

Chemical & Physical Properties

[ Molecular Formula ]:
C37H62N2O29

[ Molecular Weight ]:
998.88400

[ Exact Mass ]:
998.34400

[ PSA ]:
502.25000

Synthetic Route

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Precursor & DownStream

Precursor

DownStream