Anti-inflammatory agent 11
Names
[ CAS No. ]:
63932-07-0
[ Name ]:
Anti-inflammatory agent 11
[Synonym ]:
4-benzyl-1-(4-pyridylcarbonyl)thiosemicarbazide
4-benzyl-1-isonicotinoyl-thiosemicarbazide
4-benzyl-1-(4-pyridoyl) thiosemicarbazide
Biological Activity
[Description]:
Anti-inflammatory agent 11 (compound 16) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 11 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 1.3 and 6.9 μM, respectively. Anti-inflammatory agent 11 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 11 can be used for tuberculosis (TB) research[1].
[Related Catalog]:
[Target]
TNF-α
[In Vitro]
Anti-inflammatory agent 11 (compound 16) is active in the reduction of accumulated nitrite, with an IC50 of 64.8 ± 1.0 μM[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C14H14N4OS
[ Molecular Weight ]:
286.35
[ Exact Mass ]:
286.08900
[ PSA ]:
98.14000
[ LogP ]:
2.56340