1,2,3,4-tetrachlorobenzene
Names
[ CAS No. ]:
634-66-2
[ Name ]:
1,2,3,4-tetrachlorobenzene
[Synonym ]:
MFCD00000538
1,2,3,4-TeCB
1,2,3,4-tcb
1,2,3,4-Tetrachlorobenzene
2,3,4,5-tetrachlorobenzene
Tetrachlorobenzene
1,2,3,4,-tetrachlorobenzene
EINECS 211-214-0
1,2,3,4-tetrachloro-benzen
1,2,3,4-tetraclorobenzene
Tetrachlorobenzene,1,2,3,4
BENZENE,1,2,3,4-TETRACHLORO
Chemical & Physical Properties
[ Density]:
1,73 g/cm3
[ Boiling Point ]:
254 °C761 mm Hg(lit.)
[ Melting Point ]:
44 °C
[ Molecular Formula ]:
C6H2Cl4
[ Molecular Weight ]:
215.89200
[ Flash Point ]:
>230 °F
[ Exact Mass ]:
213.89100
[ LogP ]:
4.30020
[ Index of Refraction ]:
1.582
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DB9440000
- CHEMICAL NAME :
- Benzene, 1,2,3,4-tetrachloro-
- CAS REGISTRY NUMBER :
- 634-66-2
- BEILSTEIN REFERENCE NO. :
- 1910025
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C6-H2-Cl4
- MOLECULAR WEIGHT :
- 215.88
- WISWESSER LINE NOTATION :
- GR BG CG DG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1167 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 11,663,1983
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 4,106,1952 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2 gm/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
- REFERENCE :
- TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 29,21,1984
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1500 mg/kg
- SEX/DURATION :
- female 9-13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 26,243,1983
Safety Information
[ Symbol ]:
GHS07, GHS09
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H410
[ Precautionary Statements ]:
P273-P501
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S22-S24/25-S45-S16-S7-S36/37
[ RIDADR ]:
3077
[ WGK Germany ]:
3
[ RTECS ]:
DB9440000
[ Hazard Class ]:
9.0
Synthetic Route
Articles
Eur. J. Med. Chem. 43 , 714-40, (2008)
Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and org...
Determination of chlorobenzenes in water samples by solid-phase disk extraction and gas chromatography-electron capture detection.J. Chromatogr. Sci. 52(5) , 375-82, (2014)
A simple, rapid, sensitive and high throughput method is described, based on solid-phase disk extraction (SPDE) and gas chromatography-electron capture detection, for the determination of chlorobenzen...
Chlorocatechols substituted at positions 4 and 5 are substrates of the broad-spectrum chlorocatechol 1,2-dioxygenase of Pseudomonas chlororaphis RW71.J. Bacteriol. 183(3) , 997-1011, (2001)
The nucleotide sequence of a 10,528-bp region comprising the chlorocatechol pathway gene cluster tetRtetCDEF of the 1,2,3,4-tetrachlorobenzene via the tetrachlorocatechol-mineralizing bacterium Pseudo...