2,3-Butanedione,1,4-dibromo-
Names
[ CAS No. ]:
6305-43-7
[ Name ]:
2,3-Butanedione,1,4-dibromo-
[Synonym ]:
MFCD00000205
1,4-dibromobutane-2,3-dione
EINECS 228-615-1
Chemical & Physical Properties
[ Density]:
2.117g/cm3
[ Boiling Point ]:
213ºC at 760 mmHg
[ Melting Point ]:
117-119°C
[ Molecular Formula ]:
C4H4Br2O2
[ Molecular Weight ]:
243.88100
[ Flash Point ]:
86ºC
[ Exact Mass ]:
241.85800
[ PSA ]:
34.14000
[ LogP ]:
0.91440
[ Index of Refraction ]:
1.539
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EK2850000
- CHEMICAL NAME :
- 2,3-Butanedione, 1,4-dibromo-
- CAS REGISTRY NUMBER :
- 6305-43-7
- BEILSTEIN REFERENCE NO. :
- 0970154
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C4-H4-Br2-O2
- MOLECULAR WEIGHT :
- 243.90
- WISWESSER LINE NOTATION :
- E1VV1E
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 9400 ug/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes Nutritional and Gross Metabolic - other changes
- REFERENCE :
- JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 31,297,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00598
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 21 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - acute pulmonary edema Liver - hepatitis (hepatocellular necrosis), diffuse
- REFERENCE :
- JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 31,297,1963
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R23/24/25;R34
[ Safety Phrases ]:
S26-S36/37/39-S37/39-S27
[ RIDADR ]:
1759
[ RTECS ]:
EK2850000
[ Packaging Group ]:
III
[ Hazard Class ]:
8
[ HS Code ]:
2914700090
Synthetic Route
Customs
[ HS Code ]: 2914700090
[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%
Articles
Chem. Commun. (Camb.) (15) , 1999-2001, (2009)
Reaction of a pinene-based pyridylthioamide with 1,4-dibromo-2,3-butanedione in refluxing methanol yielded a new chiral pyridylthiazole ligand L which forms a dinuclear double-stranded helicate with C...
Cysteinyl peptides labeled by dibromobutanedione in reaction with rabbit muscle pyruvate kinase.Protein Sci. 1(5) , 678-87, (1992)
The bifunctional reagent 1,4-dibromobutanedione (DBBD) reacts covalently with pyruvate kinase from rabbit muscle to cause inactivation of the enzyme at a rate that is linearly dependent on the reagent...