3-(5-Nitro-2-furyl)acrylic Acid

Names

[ CAS No. ]:
6281-23-8

[ Name ]:
3-(5-Nitro-2-furyl)acrylic Acid

[Synonym ]:
EINECS 228-488-2
MFCD00143078
3-(5-Nitro-2-furyl)acrylic acid

Chemical & Physical Properties

[ Boiling Point ]:
348.8ºC at 760 mmHg

[ Molecular Formula ]:
C₇H₅NO₅

[ Molecular Weight ]:
183.11800

[ Flash Point ]:
164.8ºC

[ Exact Mass ]:
183.01700

[ PSA ]:
96.26000

[ LogP ]:
1.80880

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LT8566000

CHEMICAL NAME :: 2-Furanacrylic acid, 5-nitro-

CAS REGISTRY NUMBER :: 6281-23-8

LAST UPDATED :: 199410

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C7-H5-N-O5

MOLECULAR WEIGHT :: 183.13

WISWESSER LINE NOTATION :: T5OJ BNW E1U1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 5 mg/L

REFERENCE :: TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 20,377,1986

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36-43

[ Safety Phrases ]:
26-36/37

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
LT8566000

[ HS Code ]:
2932190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932190090

[ Summary ]:
2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles

Inducible stable DNA replication in Escherichia coli uvr+ and uvr- cells, treated with genotoxic chemicals.

Mutat. Res. 281(1) , 63-6, (1992)

Inducible stable DNA replication (iSDR) provoked by a damaging treatment with MMS, MNU, MNNG, NFAA, NFN, 4NQO, NAL or MMC, was followed in both repair-competent E. coli PQ35 and its uvrA derivative E....

DNA damage by 5-nitro-2-furylacrylic acid, a nitrofuran derivative.

Chem. Biol. Interact. 63(2) , 185-94, (1987)

5-Nitro-2-furylacrylic acid (5-NFA) caused dose dependent inhibition of growth of Escherichia coli K-12 strain AB 2480 (uvr-, rec-), the 37% (D37) and 10% (D10) survival doses being 1.0 microgram/ml.h...

Mutagenic effects of two nitrofuran food preservatives.

Neoplasma 29(6) , 675-84, (1982)

Two structurally related food additives, 3-(5-nitro-2-furyl)acrylic acid (5-NFAA) and 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (AF-2) showed a marked mutagenic effect on Salmonella typhimurium strain...