SIB 1893

Names

[ Name ]:
SIB 1893

Biological Activity

[Description]:

(E/Z)-SIB-1893 is a racemic compound of (E)-SIB-1893 and (Z)-SIB-1893 isomers. (E)-SIB-1893 is a selective non-competitive metabotropic glutamate subtype 5 receptor (mGluR5) antagonist[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[In Vivo]

(E)-SIB-1893 produces hypothermia in freely moving rats in a dose-dependent manner[1].

[References]

[1]. Łuszczki JJ, et al. Non-competitive metabotropic glutamate subtype 5 receptor antagonist (SIB-1893) decreases body temperature in rats. Pharmacol Rep. 2005;57(6):795-801.

Chemical & Physical Properties

[ Density]:
1.072g/cm3

[ Boiling Point ]:
307.3ºC at 760mmHg

[ Molecular Formula ]:
C₁₄H₁₃N

[ Molecular Weight ]:
195.26000

[ Flash Point ]:
128.8ºC

[ Exact Mass ]:
195.10500

[ PSA ]:
12.89000

[ LogP ]:
3.56040

[ Index of Refraction ]:
1.651

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

Related Compounds

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