2-(Benzyloxy)ethanol

Names

[ CAS No. ]:
622-08-2

[ Name ]:
2-(Benzyloxy)ethanol

[Synonym ]:
2-(Benzyloxy)ethanol
Ethanol, 2- (benzyloxy)-
2-(Benzyl-Oxy)Ethan-1-Ol
MFCD00002868
2-phenylmethoxyethanol
Benzyl cellosolve
Ethanol, 2-(phenylmethoxy)-
Glycol benzyl ether
UNII-06S8147L47
EINECS 210-719-3
ethylene glycol monobenzyl ether
Ethanol, 2- (phenylmethoxy)-

Biological Activity

[Description]:

2-(Benzyloxy)ethanol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Reed NN, et al. A one-step synthesis of monoprotected polyethylene glycol ethers. J Org Chem. 2000 Sep 8;65(18):5843-5.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
254.4±15.0 °C at 760 mmHg

[ Melting Point ]:
<-75ºC

[ Molecular Formula ]:
C₉H₁₂O₂

[ Molecular Weight ]:
152.190

[ Flash Point ]:
108.0±14.6 °C

[ Exact Mass ]:
152.083725

[ PSA ]:
29.46000

[ LogP ]:
1.38

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.525

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KJ7550000

CHEMICAL NAME :: Ethanol, 2-(benzyloxy)-

CAS REGISTRY NUMBER :: 622-08-2

BEILSTEIN REFERENCE NO. :: 2043566

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H12-O2

MOLECULAR WEIGHT :: 152.21

WISWESSER LINE NOTATION :: Q2O1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1190 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
KJ7550000

[ HS Code ]:
2909499000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Alkylation of active methylene compounds with alcohols catalyzed by an iridium complex.

Chem. Commun. (Camb.) , 2850, (2007)

Base-free catalytic alpha-alkylation of active methylene compounds with primary alcohols was successfully achieved using an [IrCl(cod)](2) complex in the presence of PPh(3) to afford the corresponding...

A structure-based library approach to kinase inhibitors. Norman TC, et al.

J. Am. Chem. Soc. 118(31) , 7430-31, (1996)

Poly (benzyloxy ethyl methacrylate): preparation by free radical polymerization and by group transfer polymerization; with subsequent debenzylation to form poly (2-hydroxyethyl methacrylate). Dyakonov TA, et al.

Eur. Polymer J. 36(9) , 1779-93, (2000)

Related Compounds

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