4-Androsten-4-ol-3,17-dione acetate
Names
[ CAS No. ]:
61630-32-8
[ Name ]:
4-Androsten-4-ol-3,17-dione acetate
[Synonym ]:
[(8R,9S,10R,13S,14S)-10,13-dimethyl-3,17-dioxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-4-yl] acetate
Chemical & Physical Properties
[ Density]:
1.18g/cm3
[ Boiling Point ]:
501.2ºC at 760 mmHg
[ Molecular Formula ]:
C21H28O4
[ Molecular Weight ]:
344.44500
[ Flash Point ]:
219.2ºC
[ Exact Mass ]:
344.19900
[ PSA ]:
60.44000
[ LogP ]:
3.97820
[ Index of Refraction ]:
1.548
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BV8153000
- CHEMICAL NAME :
- Androst-4-ene-3,17-dione, 4-hydroxy-, acetate (ester)
- CAS REGISTRY NUMBER :
- 61630-32-8
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C21-H28-O4
- MOLECULAR WEIGHT :
- 344.49
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 300 mg/kg
- SEX/DURATION :
- female 2-7 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
- REFERENCE :
- BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 18,365,1978
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Implant
- DOSE :
- 375 mg/kg
- SEX/DURATION :
- female 18 day(s) pre-mating female 1-8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)
- REFERENCE :
- BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 18,365,1978
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
BV8153000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
J. Steroid Biochem. 24 , 91, (1986)
Inhibition of aromatase to reduce estrogen production by peripheral and ovarian tissue could be a useful approach to treating hormone-dependent breast cancer. Several C19, 17 keto steroids have been i...
Inhibition of estrogen biosynthesis and regression of mammary tumors by aromatase inhibitors.Adv. Exp. Med. Biol. 138 , 179-90, (1981)
Overview of recent development of aromatase inhibitors.
Cancer Res. 42(8 Suppl) , 3312s-3314s, (1982)
Since the first publication in 1973 concerning aromatase inhibitors, several effective compounds have been reported by a number of investigators. Our studies with 4-hydroxyandrostene-3,17-dione, 4-ace...