Temocillin disodium salt

Names

[ Name ]:
Temocillin disodium salt

[Synonym ]:
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,6-((carboxy-3-thienylacetyl)amino)-6-methoxy-3,3-dimethyl-7-oxo-,disodium salt,(2S,5R,6S)
disodium,(2S,5R,6S)-6-[(2-carboxylato-2-thiophen-3-ylacetyl)amino]-6-methoxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
UNII-96IIP39ODH
Negaban (TN)
Temocillin disodium salt
EINECS 262-835-9
Temocillin sodium
Temocillin

Biological Activity

[Description]:

Temocillin disodium, a 6-α-methoxy penicillin, possesses antibacterial activity[1].

[Related Catalog]:

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Anti-infection >> Bacterial

[In Vivo]

Temocillin dosing regimens of 200 mg/kg every 4 and 6 h remained significantly effective in reducing bacterial titres in kidneys against the two strains, with no significant difference between the parental strain and its transconjugant[2].

[References]

[1]. K Jules, et al. Antibacterial activity and beta-lactamase stability of temocillin. Antimicrob Agents Chemother. 1982 Sep;22(3):453-60.

[2]. J F Soubirou, et al. Activity of temocillin in a murine model of urinary tract infection due to Escherichia coli producing or not producing the ESBL CTX-M-15. J Antimicrob Chemother. 2015 May;70(5):1466-72.

Chemical & Physical Properties

[ Density]:
1.6g/cm3

[ Boiling Point ]:
761.9ºC at 760mmHg

[ Molecular Formula ]:
C₁₆H₁₆N₂Na₂O₇S₂

[ Molecular Weight ]:
458.42

[ Flash Point ]:
414.6ºC

[ Exact Mass ]:
414.05600

[ PSA ]:
190.27000

[ LogP ]:
1.30030

Related Compounds

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