(+)-Nortrachelogenin

Names

[ Name ]:
(+)-Nortrachelogenin

[Synonym ]:
(3R,4R)-3-Hydroxy-3,4-bis(4-hydroxy-3-methoxybenzyl)dihydro-2(3H)-furanone
2(3H)-Furanone, dihydro-3-hydroxy-3,4-bis[(4-hydroxy-3-methoxyphenyl)methyl]-, (3R,4R)-
(3R-cis)-Dihydro-3,4-bis((4-hydroxy-3-methoxyphenyl)methyl)-3-hydroxy-2(3H)-furanone
2(3H)-Furanone, dihydro-3,4-bis((4-hydroxy-3-methoxyphenyl)methyl)-3-hydroxy-, (3R-cis)-

Biological Activity

[Description]:

(+)-Nortrachelogenin (Wikstromol), a pharmacologically ligand from from wikstroemia indica, possesses antileukemic activity[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

[In Vitro]

Wikstromol induces apoptosis and suppresses migration of MDA-MB-231 cells via inhibiting PI3K/Akt pathway[2].

[References]

[1]. A Kato,et al. (+)-Nortrachelogenin, A New Pharmacologically Active Lignan From Wikstroemia indica. J Nat Prod. 1979 Mar;42(2):159-162.

[2]. Huankai Yao, et al. Wikstromol from Wikstroemia indica induces apoptosis and suppresses migration of MDA-MB-231 cells via inhibiting PI3K/Akt pathway.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
609.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₂O₇

[ Molecular Weight ]:
374.384

[ Flash Point ]:
217.3±23.6 °C

[ Exact Mass ]:
374.136566

[ PSA ]:
105.45000

[ LogP ]:
0.92

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.630

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2932209090

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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