Piperacillin

Names

[ Name ]:
Piperacillin

[Synonym ]:
Pipercillin
(2R,5R,6R)-6-{[(2R)-2-{[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino}-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
6-[[[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid
PIPC
EINECS 262-811-8
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-
PIPERACILLIN SODIUM
PIPERACILLIN NA
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-, (2R,5R,6R)-
Piperacillin anhydrous
6-{[{[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino}(phenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
MFCD00917471
PIPERAILLIN
Pipracil

Biological Activity

[Description]:

Piperacillin is kind of semisynthetic penicillins. Piperacillin has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Piperacillin has shown greater activity against β-lactamase-producing organisms than the other penicillins[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. B. Holmes, et al. A Review of its Antibacterial Activity, Pharmacokinetic Properties and Therapeutic Use.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Melting Point ]:
139-140ºC

[ Molecular Formula ]:
C₂₃H₂₇N₅O₇S

[ Molecular Weight ]:
517.555

[ Exact Mass ]:
517.163147

[ PSA ]:
181.73000

[ LogP ]:
1.88

[ Index of Refraction ]:
1.678

[ Storage condition ]:
Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XH8952200

CHEMICAL NAME :: 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-6-(((((4-ethyl-2,3-dioxo- 1-piperazinyl)carbonyl)amino)phenylacetyl)amino)-7-ox o-, (2S-(2-alpha,5-alpha,6-beta(S*)))-

CAS REGISTRY NUMBER :: 61477-96-1

LAST UPDATED :: 199706

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C23-H27-N5-O7-S

MOLECULAR WEIGHT :: 517.61

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 97,987,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5651 No. of Facilities: 148 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 9665 (estimated) No. of Female Employees: 8470 (estimated)

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
42/43

[ Safety Phrases ]:
36/37

[ HS Code ]:
2941101900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2941101900

Related Compounds

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