M62812

Names

[ Name ]:
M62812

[Synonym ]:
6-(2-Aminophenoxy)-1,2-benzisothiazol-3-amine dihydrochloride
1,2-Benzisothiazol-3-amine, 6-(2-aminophenoxy)-, hydrochloride (1:2)
6-(2-Aminophenoxy)-1,2-benzothiazol-3-amine dihydrochloride
MFCD30179737

Biological Activity

[Description]:

M62812 is a toll-like receptor 4 (TLR4) signaling inhibitor. M62812 inhibits endothelial and leukocyte activation and prevents lethal septic shock in mice. M62812 can reduces LPS-induced coagulation and inflammatory responses. M62812 can be used for the research of sepsis[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)

Research Areas >> Infection

[References]

[1]. Nakamura M, et al. Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice. Eur J Pharmacol. 2007 Aug 27;569(3):237-43.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₃Cl₂N₃OS

[ Molecular Weight ]:
330.23

[ Exact Mass ]:
329.015625