4-Methoxybiphenyl

Names

[ CAS No. ]:
613-37-6

[ Name ]:
4-Methoxybiphenyl

[Synonym ]:
EINECS 210-339-8
MFCD00014897
1-methoxy-4-phenylbenzene

Chemical & Physical Properties

[ Boiling Point ]:
157 °C (10 mmHg)

[ Melting Point ]:
86-90 °C(lit.)

[ Molecular Formula ]:
C₁₃H₁₂O

[ Molecular Weight ]:
184.23400

[ Flash Point ]:
157°C/10mm

[ Exact Mass ]:
184.08900

[ PSA ]:
9.23000

[ LogP ]:
3.36220

[ Index of Refraction ]:
1.556

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BZ8850000

CHEMICAL NAME :: Anisole, p-phenyl-

CAS REGISTRY NUMBER :: 613-37-6

BEILSTEIN REFERENCE NO. :: 2043157

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H12-O

MOLECULAR WEIGHT :: 184.25

WISWESSER LINE NOTATION :: 1OR DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5477 mg/kg/52W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Blood - lymphoma, including Hodgkin's disease

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,270,1962

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
BZ8850000

[ HS Code ]:
2909309090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909309090

[ Summary ]:
2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

A comparison of biphenyl 4-hydroxylation and 4-methoxybiphenyl O-demethylation in rat liver microsomes.

Biochem. Pharmacol. 30(14) , 1915-9, (1981)

Influence of the sulphation inhibitor, 2,6-dichloro-4-nitrophenol, on the production and conjugation, of 4-hydroxybiphenyl generated from 4-methoxybiphenyl by rat isolated hepatocytes.

Biochem. Pharmacol. 36(18) , 3090-2, (1987)

Influence of cytochrome P-450 type on the pattern of conjugation of 4-hydroxybiphenyl generated from biphenyl or 4-methoxybiphenyl.

Xenobiotica 15(6) , 493-502, (1985)

The rate of production of 4-hydroxybiphenyl from 4-methoxybiphenyl in hepatocytes isolated from untreated rats was essentially identical to that from biphenyl in hepatocytes isolated from rats pretrea...