4,4'-Bi-o-toluidine dihydrochloride
Names
[ CAS No. ]:
612-82-8
[ Name ]:
4,4'-Bi-o-toluidine dihydrochloride
[Synonym ]:
(1,1'-Biphenyl)-4,4'-diamine, 3,3'-dimethyl-, dihydrochloride
O-TOLIDINE HYDROCHLORIDE
3,3'-Dimethyl-[1,1'-biphenyl]-4,4'-diamine dihydrochloride
8-Piperazin-1-yl-quinoline
MFCD00012960
3,3'-Dimethyl-4,4'-biphenyldiamine dihydrochloride
3,3'-Dimethyl-benzidin,Dihydrochlorid
o-Tolidine dihydroch
3,3'-Dimethylbiphenyl-4,4'-diamine dihydrochloride
Benzidine, 3,3'-dimethyl-, dihydrochloride
[1,1'-Biphenyl]-4,4'-diamine, 3,3'-dimethyl-, dihydrochloride
3,3′-Dimethylbenzidine dihydrochloride
3,3'-dimethyl-benzidine,dihydrochloride
3,3'-dimethylbenzidine diammonium chloride
O-TolidineHydrochlorideGr
EINECS 210-322-5
o-Tolidine2HCl
THALLIUM ARSENATE
O-TOLIDINE DI HCL
4,4'-Bi-o-toluidine dihydrochloride
[1,1'-Biphenyl]-4,4'-diamine, 3,3'-dimethyl-, hydrochloride (1:2)
3,3'-Dimethylbenzidine dihydrochloride
4,4′-Diamino-3,3′-dimethylbiphenyl dihydrochloride
3,3'-Dimethyl-4,4'-diaminobiphenyl dihydrochloride
O-TOLIDINE DIHYDROCHLORIDE
ZR B1 DR DZ C1 &&2HCl
Chemical & Physical Properties
[ Boiling Point ]:
361ºC at 760 mmHg
[ Melting Point ]:
>300°C
[ Molecular Formula ]:
C14H18Cl2N2
[ Molecular Weight ]:
285.212
[ Exact Mass ]:
284.084717
[ PSA ]:
52.04000
[ LogP ]:
5.90120
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DD1226000
- CHEMICAL NAME :
- Benzidine, 3,3'-dimethyl-, dihydrochloride
- CAS REGISTRY NUMBER :
- 612-82-8
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 13
- MOLECULAR FORMULA :
- C14-H16-N2.2Cl-H
- MOLECULAR WEIGHT :
- 285.24
- WISWESSER LINE NOTATION :
- ZR B1 DR DZ C1 &GH 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1120 mg/kg/14D-C
- TOXIC EFFECTS :
- Endocrine - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 18200 mg/kg/13W-C
- TOXIC EFFECTS :
- Endocrine - changes in thymus weight Blood - changes in bone marrow (not otherwise specified) Blood - changes in erythrocyte (RBC) count
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1820 mg/kg/65W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Skin and Appendages - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 15288 mg/kg/78W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- Specific locus test
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 20 mg/L
- REFERENCE :
- NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-390,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1372 No. of Facilities: 132 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 1178 (estimated) No. of Female Employees: 105 (estimated)
Safety Information
[ Symbol ]:
GHS07, GHS08, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H302-H350-H411
[ Precautionary Statements ]:
P201-P273-P301 + P312 + P330-P308 + P313-P391-P501
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
T:Toxic;N:Dangerousfortheenvironment;
[ Risk Phrases ]:
R22;R45;R51/53;R68
[ Safety Phrases ]:
S53-S45-S61
[ RIDADR ]:
UN 3077 9/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
DD1226000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
Precursor & DownStream
Precursor
DownStream
Articles
Environ. Mol. Mutagen. 48(5) , 404-13, (2007)
4-Aminobyphenyl (4-Ab), benzidine (Bz), and Bz congeners were evaluated for their ability to induce genotoxicity through an oxidative mechanism. The mutagenicity of these compounds was tested in the p...
ortho-Substituent effects on the in vitro and in vivo genotoxicity of benzidine derivatives.Mutat. Res. 319(1) , 19-30, (1993)
Benzidine and its 3,3'-diamino, 3,3'-dimethyl, 3,3'-dimethoxy, 3,3'-difluoro, 3,3'-dichloro, 3,3'-dibromo, 3,3'-dicarbomethoxy and 3,3'-dinitro derivatives together with 2-nitrobenzidine and 3-nitrobe...
Iron(III) oxidized nucleophilic coupling of catechol with o-tolidine/p-toluidine followed by 1,10-phenanthroline as new and sensitivity improved spectrophotometric methods for iron present in chemicals, pharmaceutical, edible green leaves, nuts and lake water samples.Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 86 , 152-8, (2012)
A nucleophile formed from iron(III) oxidized catechol in 0.1M hydrochloric acid couple with o-tolidine, system 1/p-toluidine, system 2 to produce dye product, λ max 520 nm. The system 1/2 obeys Beer's...