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4,4'-Methylene di-o-toluidine

Names

[ CAS No. ]:
838-88-0

[ Name ]:
4,4'-Methylene di-o-toluidine

[Synonym ]:
4,4'-Diamino-3,3'-dimethyldiphenylmethane
4,4'-Methylene di-o-toluidine
Benzenamine, 4,4'-methylenebis[2-methyl-
MFCD00126963
4,4'-Methylen-bis(2-methyl aniline)
EINECS 212-658-8
4,4'-Methylenebis(2-methylaniline)
4,4'-Methylene-di(o-toluidine)
4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline
4,4'-methanediylbis(2-methylaniline)
Methane, bis[4-amino-3-methylphenyl]-
4,4'-Methylene-bis(2-methylaniline)

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
406.6±40.0 °C at 760 mmHg

[ Melting Point ]:
155-157 °C

[ Molecular Formula ]:
C15H18N2

[ Molecular Weight ]:
226.317

[ Flash Point ]:
238.9±26.8 °C

[ Exact Mass ]:
226.147003

[ PSA ]:
52.04000

[ LogP ]:
2.56

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.634

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BY5300000
CHEMICAL NAME :
Aniline, 4,4'-methylenebis(2-methyl-
CAS REGISTRY NUMBER :
838-88-0
BEILSTEIN REFERENCE NO. :
0398069
LAST UPDATED :
199701
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C15-H18-N2
MOLECULAR WEIGHT :
226.35
WISWESSER LINE NOTATION :
ZR B1 D1R DZ C1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4656 mg/kg/55W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
4900 mg/kg/4Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4820 mg/kg/69W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6500 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
1 mg/plate
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 49,185,1982 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,248,1987 IARC Cancer Review:Human Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,248,1987 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,248,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FRANCE;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-SWITZERLAND;Carcinogen JAN 1993

Safety Information

[ Symbol ]:

GHS07, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H317-H350-H410

[ Precautionary Statements ]:
P201-P273-P280-P308 + P313-P501

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T: Toxic;N: Dangerous for the environment;

[ Risk Phrases ]:
R45;R22;R43;R50/53

[ Safety Phrases ]:
S53-S45-S60-S61

[ RIDADR ]:
UN 3077 9/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
BY5300000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2921590090

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2921590090

[ Summary ]:
2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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