8-Methylquinoline
Names
[ CAS No. ]:
611-32-5
[ Name ]:
8-Methylquinoline
[Synonym ]:
Quinoline,8-methyl
8-methyl quinoline
Quinoline, 8-methyl-
8-Methyl-chinolin
O-Toluquinoline
MFCD00006810
8-Methylquinoline
EINECS 210-264-0
Fasudil Impurity 11
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
247.5±0.0 °C at 760 mmHg
[ Melting Point ]:
-80 °C
[ Molecular Formula ]:
C10H9N
[ Molecular Weight ]:
143.185
[ Flash Point ]:
105.0±0.0 °C
[ Exact Mass ]:
143.073502
[ PSA ]:
12.89000
[ LogP ]:
2.54
[ Vapour Pressure ]:
0.0±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.625
[ Water Solubility ]:
0.1-0.5 g/100 mL at 17 ºC
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VC0562000
- CHEMICAL NAME :
- Quinoline, 8-methyl-
- CAS REGISTRY NUMBER :
- 611-32-5
- BEILSTEIN REFERENCE NO. :
- 0111340
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C10-H9-N
- MOLECULAR WEIGHT :
- 143.20
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
- TYPE OF TEST :
- Unscheduled DNA synthesis
- TEST SYSTEM :
- Rodent - rat Liver
- DOSE/DURATION :
- 1 mmol/L
- REFERENCE :
- CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 12,217,1991
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R22;R36/37/38;R68
[ Safety Phrases ]:
S26-S36-S45-S36/37/39
[ RIDADR ]:
2810.0
[ WGK Germany ]:
3
[ RTECS ]:
VC0562000
[ Hazard Class ]:
6.1
[ HS Code ]:
2933499090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933499090
[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
J. Biotechnol. 88(2) , 167-71, (2001)
P450 monooxygenases from microorganisms, similar to those of eukaryotic mitochondria, display a rather narrow substrate specificity. For native P450 BM-3, no other substrates than fatty acids or an in...
The hepatic metabolism of two methylquinolines.Carcinogenesis 14(5) , 1041-7, (1993)
The hepatic microsomal metabolism of the carcinogenic 8-methylquinoline (8MQ) and its noncarcinogenic isomer, 6-methylquinoline (6MQ), were compared for preparations from control rats and rats pretrea...
Carcinogenicity of quinoline, 4- and 8-methylquinoline and benzoquinolines in newborn mice and rats.Food Chem. Toxicol. 26(7) , 625-9, (1988)
The relative tumorigenic activity of quinoline, 4-methylquinoline, 8-methylquinoline, and all three isomeric benzoquinolines was evaluated in newborn CD-1 mice and Sprague-Dawley rats. In the newborn-...