4-Methylcumarin
Names
[ CAS No. ]:
607-71-6
[ Name ]:
4-Methylcumarin
[Synonym ]:
4-methyl-2H-2-chromenone
4-Methyl-2H-1-benzopyran-2-one
4-Methylcumarin
EINECS 210-141-1
4-Methyl-2H-chromen-2-one
COUMARIN,4-METHYL
2H-1-Benzopyran-2-one,4-methyl
4-Methyl-chromen-2-one
4-methyl-coumarin
Chemical & Physical Properties
[ Density]:
1.185 g/cm3
[ Boiling Point ]:
296.9ºC at 760 mmHg
[ Melting Point ]:
81 °C
[ Molecular Formula ]:
C10H8O2
[ Molecular Weight ]:
160.16900
[ Flash Point ]:
120.6ºC
[ Exact Mass ]:
160.05200
[ PSA ]:
30.21000
[ LogP ]:
2.10140
[ Index of Refraction ]:
1.572
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GN7791000
- CHEMICAL NAME :
- Coumarin, 4-methyl-
- CAS REGISTRY NUMBER :
- 607-71-6
- BEILSTEIN REFERENCE NO. :
- 0121648
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C10-H8-O2
- MOLECULAR WEIGHT :
- 160.18
- WISWESSER LINE NOTATION :
- T66 BOVJ E1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1691 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 83,1124,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1088 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 76,186,1956 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1121 mg/kg/7D-I
- TOXIC EFFECTS :
- Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other hydrolases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 16,626,1970 *** REVIEWS *** TOXICOLOGY REVIEW PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 10,85,1974
Safety Information
[ HS Code ]:
2932209090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2932209090
[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%