3’-O-Methyluridine

Names

[ Name ]:
3’-O-Methyluridine

[Synonym ]:
3'-O-Methyl-uridin
O3'-methyl-uridine
3'-O-methyluridine

Biological Activity

[Description]:

3’-O-Methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.53g/cm3

[ Molecular Formula ]:
C₁₀H₁₄N₂O₆

[ Molecular Weight ]:
258.23

[ Exact Mass ]:
258.08500

[ PSA ]:
113.78000

[ Index of Refraction ]:
1.611

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Differentiation of 2'-O- and 3'-O-methylated ribonucleosides by tandem mass spectrometry.

J. Am. Soc. Mass Spectrom. 17 , 1096-1099, (2006)

Recent studies revealed that the 3'-terminal nucleotides in plant microRNAs were methylated on the ribose at the 2' or 3' hydroxyl groups. Here we examined the fragmentation of the electrospray-produc...