DL-Homocysteine

Names

[ Name ]:
DL-Homocysteine

[Synonym ]:
(2S)-2-amino-4-sulfanylbutanoic acid
Homocysteine, L-
L-2-Amino-4-Mercapto-butyric acid
(S)-2-amino-4-mercapto-Butanoic acid
DL-2-amino-4-mercapto-Butyric acid
HOMO-CYS
H-Hcys-OH
Butyric acid, 2-amino-4-mercapto-
DL-2-Amino-4-mercaptobutyric acid
Butyric acid, 2-amino-4-mercapto-, DL-
(S)-2-Amino-4-mercaptobutanoic acid
2-Amino-4-mercaptobutyric acid
D,L-Homocysteine
Butanoic acid, 2-amino-4-mercapto-, (S)-
(S)-homocysteine
MFCD00151320
Butanoic acid, 2-amino-4-mercapto-
2-amino-4-mercapto-DL-Butyric acid
2-amino-4-sulfanylbutanoic acid
EINECS 227-891-0
D,L-homocystine
Homocysteine (VAN)
2-Amino-4-Mercapto-Butyric Acid
(S)-2-Amino-4-mercaptobutyric acid
(±)-Homocysteine
2-amino-4-mercapto-Butanoic acid
UNII:S7IJP4A89K
Homocysteine
Butyric acid, 2-amino-4-mercapto-, DL- (9CI)

Biological Activity

[Description]:

L-Homocysteine, a homocysteine metabolite, is a homocysteine that has L configuration. L-Homocysteine induces upregulation of cathepsin V that mediates vascular endothelial inflammation in hyperhomocysteinaemia[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

Human Endogenous Metabolite

[References]

[1]. Finkelstein JD, et al. Homocysteine. Int J Biochem Cell Biol. 2000 Apr;32(4):385-9.

[2]. Leng YP, et al. l-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia. Br J Pharmacol. 2018 Apr;175(8):1157-1172.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
299.7±35.0 °C at 760 mmHg

[ Melting Point ]:
231 °C

[ Molecular Formula ]:
C₄H₉NO₂S

[ Molecular Weight ]:
135.185

[ Flash Point ]:
135.0±25.9 °C

[ Exact Mass ]:
135.035400

[ PSA ]:
102.12000

[ LogP ]:
0.22

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.538

[ Storage condition ]:
?20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Biomarkers of one-carbon metabolism are associated with biomarkers of inflammation in women.

J. Nutr. 144(5) , 714-21, (2014)

Folate-mediated one-carbon metabolism is essential for DNA synthesis, repair, and methylation. Perturbations in one-carbon metabolism have been implicated in increased risk of some cancers and may als...

Abstracts of the 9th International Conference On Homocysteine and One-Carbon Metabolism - HCY2013. Dublin, Ireland. September 8-12, 2013.

J. Inherit. Metab. Dis. 36 Suppl 1 , S1-54, (2013)

Derivation and validation of homocysteine score in u.s. Men and women.

J. Nutr. 145(1) , 96-104, (2015)

One-carbon metabolism, which is crucial in DNA synthesis and genomic stability, is an interrelated network of biochemical reactions involved in several dietary and lifestyle factors. The development o...