Taspine

Names

[ CAS No. ]:
602-07-3

[ Name ]:
Taspine

[Synonym ]:
1-(2-Dimethylamino-aethyl)-3,8-dimethoxy-chromeno[5,4,3-cde]chromen-5,10-dion
1-[2-(dimethylamino)ethyl]-3,8-dimethoxy-1-(2-oxoethyl)[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione
3,8-Dimethoxy-1-[2-(dimethylamino)ethyl][1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione
1-[2-(dimethylamino)ethyl]-3,8-dimethoxychromeno[5,4,3-cde]chromene-5,10-dione

Biological Activity

[Description]:

Taspine is a natural product with anti-inflammatory activity. Taspine suppresses P2X4 receptor activity via PI3K inhibition. Taspine inhibits pro-inflammatory signalling via inhibition of P2X4 receptors in macrophage[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor

[References]

[1]. Izzuddin Bin Nadzirin, et al. Taspine is a natural product that suppresses P2X4 receptor activity via phosphoinositide 3-kinase inhibition. Br J Pharmacol. 2021 Dec;178(24):4859-4872.

Chemical & Physical Properties

[ Density]:
1.35g/cm3

[ Boiling Point ]:
569.6ºC at 760 mmHg

[ Melting Point ]:
>300ºC (dec.)

[ Molecular Formula ]:
C₂₀H₁₉NO₆

[ Molecular Weight ]:
369.36800

[ Flash Point ]:
298.3ºC

[ Exact Mass ]:
369.12100

[ PSA ]:
82.12000

[ LogP ]:
2.61170

[ Index of Refraction ]:
1.62

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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