2',2'-Dimethyl-2H,2'H-3,8'-bichromene-5',7-diol

Names

[ Name ]:
2',2'-Dimethyl-2H,2'H-3,8'-bichromene-5',7-diol

[Synonym ]:
2',2'-Dimethyl-2H,2'H-3,8'-bichromene-5',7-diol
Glabrene
[3,8'-Bi-2H-1-benzopyran]-5',7-diol, 2',2'-dimethyl-

Biological Activity

[Description]:

Glabrene, an isoflavene derived from licorice root, shows estrogen-like activity. Glabrene is a tyrosinase inhibitor with an IC50 of 3.5 μM[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase

[Target]

IC50: 3.5 μM (Tyrosinase)[2]

[References]

[1]. Somjen D, et al. Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues. J Steroid Biochem Mol Biol. 2004 Aug;91(4-5):241-6.

[2]. Nerya O, et al. Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots. J Agric Food Chem. 2003 Feb 26;51(5):1201-7

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
536.3±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₈O₄

[ Molecular Weight ]:
322.354

[ Flash Point ]:
278.2±30.1 °C

[ Exact Mass ]:
322.120514

[ PSA ]:
58.92000

[ LogP ]:
6.72

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.647

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2905399090

Customs

[ HS Code ]: 2905399090

[ Summary ]:
2905399090 other diols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

Related Compounds

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