Eniluracil

Names

[ Name ]:
Eniluracil

[Synonym ]:
ethynyluracil
5-ETHYNYLURACIL
Compound 776C
Eniluracil
ethynyluracyl
GW776C85
776C85

Biological Activity

[Description]:

Eniluracil (5-Ethynyluracil), a uracil analogue and a mechanism-based irreversible inhibitor of dihydropyrimidine dehydrogenase (DPD), increases the oral bioavailability of 5-fluorouracil (5-FU) to 100%, facilitating uniform absorption and predictable toxicity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

Dihydropyrimidine dehydrogenase[1]

[References]

[1]. Schilsky RL, et al. Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase. Expert Opin Investig Drugs. 2000 Jul;9(7):1635-49.

Chemical & Physical Properties

[ Density]:
1.39g/cm3

[ Melting Point ]:
320 °C(dec.)

[ Molecular Formula ]:
C₆H₄N₂O₂

[ Molecular Weight ]:
136.10800

[ Exact Mass ]:
136.02700

[ PSA ]:
65.72000

[ Index of Refraction ]:
1.589

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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