AC 55649

Names

[ Name ]:
AC 55649

[Synonym ]:
MFCD00157040
4-Octyl-4'-biphenylcarboxylic acid
8BCA
4-n-octylbiphenyl-4'-carboxylic acid
4'-Octylbiphenyl-4-carboxylic acid
octyldiphenylcarboxylic acid
4'-octyl-4-phenylbenzoic acid
4'-octyloxy-4-biphenylcarboxylic acid

Biological Activity

[Description]:

AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR

Research Areas >> Others

[Target]

RARβ2:6.9 (pEC50)

[In Vitro]

AC-55649 is a potent, highly isoform-selective agonist at the human RARβ2 receptor, with a pEC50 of 6.9[1]. AC-55649 is a potent and selective activator of RARβ2 transcriptional activity[2].

[References]

[1]. Lund BW, et al. Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist. J Med Chem. 2005 Dec 1;48(24):7517-9.

[2]. Piu F, et al. Identification of novel subtype selective RAR agonists. Biochem Pharmacol. 2005 Dec 19;71(1-2):156-62.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.037g/cm3

[ Boiling Point ]:
462ºC at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₆O₂

[ Molecular Weight ]:
310.43000

[ Flash Point ]:
216.9ºC

[ Exact Mass ]:
310.19300

[ PSA ]:
37.30000

[ LogP ]:
5.95480

[ Index of Refraction ]:
1.548

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Statements ]:
H413

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2916399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%