Ganglioside GT1b Mixture (bovine) (ammonium salt)

[ Molecular Formula ]:
C₉₅H₁₇₄N₈O₄₇

[ Molecular Weight ]:
2180.424

[ Exact Mass ]:
2179.147217

[ PSA ]:
841.40000

[ Storage condition ]:
−20°C

[ Water Solubility ]:
DMSO: soluble

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29400090

Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity.

Biochemistry 52(22) , 3930-8, (2013)

Botulinum neurotoxins (BoNTs) block neurotransmitter release by proteolyzing SNARE proteins in peripheral nerve terminals. Entry into neurons occurs subsequent to interaction with gangliosides and a s...

Distribution of mono-, di- and trisialo gangliosides in the brain of Actinopterygian fishes

Biochim. Biophys. Acta 1820(9) , 1437-43, (2012)

Background Mono-, di- and trisialo gangliosides are major glycosphingolipids in the brain of higher vertebrates involved in lipid raft assembly. In contrast, the fish brain is abundant in polisialo-ga...

Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex.

Proc. Natl. Acad. Sci. U. S. A. 85 , 7351-7355, (1988)

Using a sensitive histofluorescence staining method that allows for a quantitation of neuronal death, we compared the protective effects of gangliosides (a group of naturally occurring glycosphingolip...

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