N-Butylurea
Names
[ CAS No. ]:
592-31-4
[ Name ]:
N-Butylurea
[Synonym ]:
EINECS 209-748-4
Urea,butyl
1-Butylurea
MFCD00007956
Urea,N-butyl
butylamine amide
1-n-butylurea
N-BUTYLUREA
Chemical & Physical Properties
[ Density]:
0.962 g/cm3
[ Boiling Point ]:
179.4ºC at 760 mmHg
[ Melting Point ]:
95-98 °C(lit.)
[ Molecular Formula ]:
C5H12N2O
[ Molecular Weight ]:
116.16200
[ Flash Point ]:
62.3ºC
[ Exact Mass ]:
116.09500
[ PSA ]:
55.12000
[ LogP ]:
1.54600
[ Index of Refraction ]:
1.449
[ Water Solubility ]:
soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YS3675000
- CHEMICAL NAME :
- Urea, butyl-
- CAS REGISTRY NUMBER :
- 592-31-4
- BEILSTEIN REFERENCE NO. :
- 1744775
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C5-H12-N2-O
- MOLECULAR WEIGHT :
- 116.19
- WISWESSER LINE NOTATION :
- ZVM4
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1255 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 382 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1285 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1627 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic Behavioral - somnolence (general depressed activity)
- TYPE OF TEST :
- Cytogenetic analysis
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Fibroblast
- DOSE/DURATION :
- 4 gm/L/48H
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 48,337,1977
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R20/21/22;R37;R68
[ Safety Phrases ]:
S45-S36/37
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
YS3675000
[ HS Code ]:
2924199090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2924199090
[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
J. Am. Chem. Soc. 127(51) , 18133-42, (2005)
An exceptionally strong quadruply hydrogen-bonded complex is formed between 2,7-diamido-1,8-naphthyridine 3 (DAN) and the butylurea of guanosine 6 (UG) in chloroform. The UG unit can be prepared in fo...
Comparative evaluation of fifteen anti-sickling agents.Blood 61(4) , 693-704, (1983)
Fifteen compounds reported to be inhibitors of gelation or sickling were studied by standard methods. These tests included (1) the determination of the solubility of deoxyhemoglobin S or Csat, (2) eva...
Discovery of novel benzothiazolesulfonamides as potent inhibitors of HIV-1 protease.Bioorg. Med. Chem. 11(22) , 4769-77, (2003)
The human immunodeficiency virus (HIV) has been shown to be the causative agent for AIDS. The HIV virus encodes for a unique aspartyl protease that is essential for the production of enzymes and prote...