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Pamatolol

Names

[ CAS No. ]:
59110-35-9

[ Name ]:
Pamatolol

[Synonym ]:
Pamatolol [INN]
Pamatololum [INN-Latin]
Pamatololum
UNII-20G2S6V53L
Pamatolol
Methyl N-(4-(2-hydroxy-3-(isopropylamino)propoxy)phenethyl)carbamat

Biological Activity

[Description]:

Pamatolol is a cardioselective beta-adrenoceptor antagonist without sympathomimetic activity.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Research Areas >> Cardiovascular Disease

[In Vivo]

Pamatolol is well absorbed in the gastro-intestinal tract and excreted in the urine of man, dogs, rats and mice after oral administration, mainly in unchanged form, within 24 hrs[1].

[Animal admin]

Three male Sprague-Dawley rats weighing 200-250 g are given pamatolol-sulphate dissolved in water at a dose of 50 mg/kg (10 μCi/mg) by means of a stomach tube. The rats are housed in metabolic cages that allows for separate collection of urine and feces for a 24 hr period. They are given a commercial pellet diet and drinking water ad libitum.

[References]

[1]. Hoffmann KJ, et al. Species differences in the metabolism of pamatolol, a cardioselective beta--adrenoceptor antagonist. Eur J Drug Metab Pharmacokinet. 1979;4(3):163-73.


[Related Small Molecules]

Isoprenaline hydrochloride | ICI 118,551 (hydrochloride) | Phenylephrine hydrochloride | Yohimbine hydrochloride | Adrenaline | Ivabradine hydrochloride | Prazosin hydrochloride | Clenbuterol hydrochloride | Phentolamine mesilate | guanfacine hydrochloride | pimozide | Sotalol hydrochloride | Carvedilol | Atenolol | Metroprolol succinate

Chemical & Physical Properties

[ Density]:
1.103g/cm3

[ Boiling Point ]:
487ºC at 760 mmHg

[ Molecular Formula ]:
C16H26N2O4

[ Molecular Weight ]:
310.38900

[ Flash Point ]:
248.3ºC

[ Exact Mass ]:
310.18900

[ PSA ]:
79.82000

[ LogP ]:
2.10460

[ Index of Refraction ]:
1.518

[ Storage condition ]:
2-8℃

Related Compounds