6-Oxoprostaglandin F1α

Names

[ Name ]:
6-Oxoprostaglandin F1α

[Synonym ]:
Prost-13-en-1-oic acid, 9,11,15-trihydroxy-6-oxo-, (9α,11α,13E,15S)-
6-Oxoprostaglandin F1α
6-KETO-PROSTAGLANDIN F1ALPHA
6-OXO-9ALPHA,11ALPHA,15S-TRIHYDROXY-PROST-13E-EN-1-OIC ACID
Prosta-13-en-1-oic acid, 9,11,15-trihydroxy-6-oxo-, (9α,11α,13E,15S)-
6-oxo-prostaglandin F1alpha
6-Oxoprostaglandin F1alpha
6-KETOPROSTAGLANDIN F1A
(9α,11α,13E,15S)-9,11,15-Trihydroxy-6-oxoprost-13-en-1-oic acid
6-Keto Prostaglandin
7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]-6-oxoheptanoic acid

Biological Activity

[Description]:

6-keto Prostaglandin F1α is an endogenous metabolite present in Cerebrospinal_Fluid, Urine and Blood that can be used for the research of Meningitis, Rheumatoid Arthritis and Cardiopulmonary Resuscitation[1][2][3][4].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

Human Endogenous Metabolite

[In Vitro]

Endogenous metabolites is defined as those that are annotated by Kyoto Encyclopedia of Genes and Genomes as substrates or products of the ~1900 metabolic enzymes encoded in our genome. It is clear in the body of literature that there are documented toxic properties for many of these metabolites[1].

[References]

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.

[2]. Westcott JY, et al. Eicosanoids in human ventricular cerebrospinal fluid following severe brain injury. Prostaglandins. 1987 Dec;34(6):877-87.

[3]. Laitinen O, et al. Plasma levels and urinary excretion of prostaglandins in patients with rheumatoid arthritis. Clin Rheumatol. 1983 Dec;2(4):401-6.

[4]. Strohmenger HU, et al. Concentrations of prolactin and prostaglandins during and after cardiopulmonary resuscitation. Crit Care Med. 1995 Aug;23(8):1347-55.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
575.3±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₃₄O₆

[ Molecular Weight ]:
370.480

[ Flash Point ]:
315.8±26.6 °C

[ Exact Mass ]:
370.235535

[ PSA ]:
115.06000

[ LogP ]:
0.93

[ Vapour Pressure ]:
0.0±3.6 mmHg at 25°C

[ Index of Refraction ]:
1.561

Safety Information

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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