5'-O-DMT-5-I-2'-OMe-rU

Names

[ Name ]:
5'-O-DMT-5-I-2'-OMe-rU

[Synonym ]:
5'-O-DMT-5-I-2'-OMe-rU

Biological Activity

[Description]:

2’-O-Methyl-5’-O-DMTr-5-iodouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₁H₃₁IN₂O₈

[ Molecular Weight ]:
686.49

[ Exact Mass ]:
686.11300

[ PSA ]:
121.24000

[ LogP ]:
3.44040

5'-O-DMT-5-I-2'-OMe-rU

Names

Biological Activity

Chemical & Physical Properties

Related Compounds