1-Methoxyacetone
Names
[ CAS No. ]:
5878-19-3
[ Name ]:
1-Methoxyacetone
[Synonym ]:
MFCD00008768
1-Methoxyacetone
EINECS 227-549-0
1-methoxypropan-2-one
2-Propanone, 1-methoxy-
Chemical & Physical Properties
[ Density]:
0.9±0.1 g/cm3
[ Boiling Point ]:
118.9±13.0 °C at 760 mmHg
[ Melting Point ]:
78ºC
[ Molecular Formula ]:
C4H8O2
[ Molecular Weight ]:
88.105
[ Flash Point ]:
25.0±0.0 °C
[ Exact Mass ]:
88.052429
[ PSA ]:
26.30000
[ LogP ]:
-0.53
[ Vapour Pressure ]:
16.3±0.2 mmHg at 25°C
[ Index of Refraction ]:
1.373
[ Storage condition ]:
Flammables area
[ Water Solubility ]:
miscible
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UC2988600
- CHEMICAL NAME :
- 2-Propanone, 1-methoxy-
- CAS REGISTRY NUMBER :
- 5878-19-3
- BEILSTEIN REFERENCE NO. :
- 1560175
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C4-H8-O2
- MOLECULAR WEIGHT :
- 88.12
- WISWESSER LINE NOTATION :
- 1V1O1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,704,1986
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,704,1986 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8980 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 28,313,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >20 mL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 28,313,1974
Safety Information
[ Symbol ]:
GHS02
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H226
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xn: Harmful;F: Flammable;
[ Risk Phrases ]:
R10
[ Safety Phrases ]:
S16-S29-S33
[ RIDADR ]:
UN 1224 3/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
UC2988600
[ Packaging Group ]:
III
[ Hazard Class ]:
3.2
[ HS Code ]:
2914509090
Synthetic Route
Customs
[ HS Code ]: 2914509090
[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
Articles
J. Phys. Chem. A 109(51) , 11851-9, (2005)
The gas-phase basicities of a representative set of hydroxy- and methoxycarbonyl compounds (hydroxyacetone, 1, 3-hydroxybutanone, 2, 3-hydroxy-3-methylbutanone, 3, 1-hydroxy-2-butanone, 4, 4-hydroxy-2...
Mechanism of the double aldol reaction: the first spectroscopic characterization of a carbon-bound boron enolate derived from carboxylic esters.J. Am. Chem. Soc. 124(36) , 10759-64, (2002)
The novel doubly borylated enolate is identified as an intermediate of the double aldol reaction of acetate esters. As a precursor to the formation of the doubly borylated enolate, carbon-bound boron ...