(E)-N-[2-[2-[(2S)-1-methyl-2-piperidyl]ethyl]phenyl]-3-phenyl-prop-2-e namide

Names

[ Name ]:
(E)-N-[2-[2-[(2S)-1-methyl-2-piperidyl]ethyl]phenyl]-3-phenyl-prop-2-e namide

Biological Activity

[Description]:

Iferanserin (S-MPEC) is a selective 5-HT receptor (serotonin receptor) antagonist with an affinity for 5-HT2A receptor. Iferanserin has the potential for internal hemorrhoid disease treatment[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT2A Receptor

[In Vitro]

An intra-anal ointment application of Iferanserin might modify the vascular effects occurring in hemorrhoid disease and thereby reduce or eliminate the most frequently occurring symptoms of hemorrhoid disease[1].

[References]

[1]. Herold A, et al. Intra-anal Iferanserin 10 mg BID for hemorrhoid disease: a prospective, randomized, double-blind, placebo-controlled trial. Clin Ther. 2012 Feb;34(2):329-40.

Chemical & Physical Properties

[ Density]:
1.096g/cm3

[ Boiling Point ]:
536.4ºC at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₈N₂O

[ Molecular Weight ]:
348.48100

[ Flash Point ]:
278.2ºC

[ Exact Mass ]:
348.22000

[ PSA ]:
32.34000

[ LogP ]:
4.76630

[ Index of Refraction ]:
1.61

Synthetic Route

Click to get detail synthetic route

Related Compounds

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