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Acid Yellow 36

Names

[ CAS No. ]:
587-98-4

[ Name ]:
Acid Yellow 36

[Synonym ]:
Victoriagelb O
m-[(p-Anilinophenyl)azo]benzenesulfonic Acid Sodium Salt
Acid Yellow 36
Ext. D & C Yellow No.1
Monoazo
Sodium 3-[(E)-(4-anilinophenyl)diazenyl]benzenesulfonate
Metanil Yellow C
Benzenesulfonic acid, 3-[(E)-2-[4-(phenylamino)phenyl]diazenyl]-, sodium salt (1:1)
Metanil Yellow E
Acid Metanil Yellow
TROPAEOLIN G
Metanilgelb extra
Kiton Yellow MS
Amacid Yellow M
Sodium Salt of Metanilylazodiphenylamine
3-(4-anilino-phenylazo)-benzenesulfonic acid,sodium salt
3-(4-Anilinophenylazo)benzenesulfonic acid sodium salt
Benzenesulfonic acid, 3-[[4- (phenylamino)phenyl]azo]-, monosodium salt
sodium,3-[(4-anilinophenyl)diazenyl]benzenesulfonate
Fenazo Yellow M
Acid Golden G
sodium 3-{(E)-[4-(phenylamino)phenyl]diazenyl}benzenesulfonate
3-{[4-(phenylamino)-phenyl]azo}benzenesulfonic acid sodium salt
EINECS 209-608-2
Benzenesulfonic acid, m-[(p-anilinophenyl)azo]-, sodium salt
sodium 3-(p-anilinophenylazo)benzenesulfonate
MFCD00007486
3-(4-Anilino-phenylazo)-benzolsulfonsaeure,Natriumsalz
3-[[4-(Phenylamino)phenyl]azo]benzenesulfonic Acid Monosodium Salt

Biological Activity

[Description]:

Acid Yellow 36 (Metanil Yellow) is an azo dye and a pH indicator. Acid Yellow 36 changes its color from red at pH 1.2 to yellow at pH 2.3. Acid Yellow 36 is used in the leather, paper and textile industries. Acid Yellow 36 acts as a bifunctional inducer of specific isozymes of P-450 and cytosolic enzymes[1][2][3].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

Acid Yellow 36 (Metanil Yellow) acts as an inducer of a specific form of microsomal P-450 and cytosolic glutathione-S-transferase (GST) and quinone reductase (QR), which may involve a cytosolic Ah receptor[3].

[References]

[1]. Sharma UK, et al. Ameliorating efficacy of eugenol against metanil yellow induced toxicity in albino Wistar rats. Food Chem Toxicol. 2019;126:34-40.

[2]. Nakano N, et al. Development of a monitoring system for vinyl chloride gas in air by using an HCl monitoring tape and pyrolyzer. Talanta. 1996;43(3):459-463.

[3]. Ramchandani S, et al. Effect of oral and parenteral administration of metanil yellow on some hepatic and intestinal biochemical parameters. J Appl Toxicol. 1997;17(1):85-91.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H14N3NaO3S

[ Molecular Weight ]:
375.377

[ Exact Mass ]:
375.065369

[ PSA ]:
102.33000

[ LogP ]:
5.90350

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DB7329500
CHEMICAL NAME :
Benzenesulfonic acid, 3-((4-(phenylamino)phenyl)azo)-, monosodium salt
CAS REGISTRY NUMBER :
587-98-4
LAST UPDATED :
199709
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
C18-H14-N3-O3-S.Na
MOLECULAR WEIGHT :
375.40
WISWESSER LINE NOTATION :
WSO&R CNUNR DMR &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1800 mg/kg/90D-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Autonomic Nervous System - sympathomimetic Behavioral - alteration of operant conditioning
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6450 mg/kg/15D-I
TOXIC EFFECTS :
Gastrointestinal - other changes Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
240 mg/kg/3D-I
TOXIC EFFECTS :
Liver - other changes Biochemical - Metabolism (Intermediary) - lipids including transport
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
540 gm/kg/26W-C
TOXIC EFFECTS :
Blood - normocytic anemia Blood - changes in other cell count (unspecified) Blood - changes in erythrocyte (RBC) count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
162 gm/kg
SEX/DURATION :
male 90 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
5 mg/kg
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 31,299,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1438 No. of Facilities: 455 (estimated) No. of Industries: 10 No. of Occupations: 22 No. of Employees: 5070 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1438 No. of Facilities: 2370 (estimated) No. of Industries: 32 No. of Occupations: 33 No. of Employees: 52679 (estimated) No. of Female Employees: 18156 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R43

[ Safety Phrases ]:
S22-S24/25-S36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
DB7329500

Precursor & DownStream

Precursor

DownStream

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Effect of metanil yellow, orange II and their blend on hepatic xenobiotic metabolizing enzymes in rats.

Food Chem. Toxicol. 32(6) , 559-63, (1994)

The effects of Metanil yellow, Orange II and their blend on hepatic xenobiotic metabolizing enzymes were compared. Parenteral administration of Metanil yellow and Orange II to rats at a dose of 80 mg/...


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