Dideoxy-amanitin

Names

[ Name ]:
Dideoxy-amanitin

Biological Activity

[Description]:

Dideoxy-amanitin (compound 2), an α-Amanitin (HY-19610) derivative, is a potent and selective RNA polymerase II allosteric inhibitor with an IC50 value of 74.2 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin

[In Vitro]

Dideoxy-amanitin (compound 2; 0.078-20 μM; 24 h) has cell cytotoxicity in CHO (Chinese hamster ovary) cells with an IC50 value of 0.3 μM[1]. Cell Viability Assay[1] Cell Line: CHO (Chinese hamster ovary) cells Concentration: 0.078-20 μM Incubation Time: 24 hours Result: Decreased cell proliferation in a dose-depengdent manner.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₉H₅₄N₁₀O₁₂S

[ Molecular Weight ]:
886.97

Related Compounds

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