A 425619

Names

[ Name ]:
A 425619

[Synonym ]:
1-(4-(trifluoromethyl)benzyl)-3-(isoquinolin-5-yl)urea

Biological Activity

[Description]:

A-425619, a potent and selective TRPV1 receptor antagonist, is effective in alleviating acute and chronic inflammatory pain and postoperative pain[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Inflammation/Immunology

[In Vivo]

A-425619 (i.p., 100 μmoL/kg) 可以恢复弗氏完全佐剂（CFA；10 mg/mL）诱导的膝关节炎症引起的 C57BL/6J 小鼠自发挖掘行为的减少[1]。

[References]

[1]. Sampurna Chakrabarti, et al. Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner. Neuropharmacology. 2018 Dec;143:49-62.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₄F₃N₃O

[ Molecular Weight ]:
345.31800

[ Exact Mass ]:
345.10900

[ PSA ]:
57.51000

[ LogP ]:
4.85270

Related Compounds

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