<Suppliers Price>

Suberosin

Names

[ CAS No. ]:
581-31-7

[ Name ]:
Suberosin

[Synonym ]:
2H-1-Benzopyran-2-one, 7-methoxy-6- (3-methyl-2-butenyl)-
SUBEROSIN
7-Methoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-2-one
7-Methoxy-6-(3-methyl-2-buten-1-yl)-2H-chromen-2-one
2H-1-Benzopyran-2-one, 7-methoxy-6-(3-methyl-2-buten-1-yl)-
2H-1-Benzopyran-2-one, 7-methoxy-6-(3-methyl-2-butenyl)-
Coumarin, 7-methoxy-6- (3-methyl-2-butenyl)-
7-methoxy-6-prenylcoumarin
Coumarin, 7-methoxy-6-(3-methyl-2-butenyl)-

Biological Activity

[Description]:

Suberosin, isolated from Plumbago zeylanica, exhibits anti-inflammatory and anticoagulant activity. Suberosin suppresses PHA-induced PBMC proliferation and arrested cell cycle progression from the G1 transition to the S phase through the modulation of the transcription factors NF-AT and NF-κB[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[References]

[1]. Y-C Chen, et al. Suberosin inhibits proliferation of human peripheral blood mononuclear cells through the modulation of the transcription factors NF-AT and NF-jB. British Journal of Pharmacology (2007) 150, 298-312.

[2]. Golfakhrabadi F, et al. Anticoagulant activity of isolated coumarins (suberosin and suberenol) and toxicity evaluation of Ferulago carduchorum in rats. Pharm Biol. 2014 Oct;52(10):1335-40.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
393.3±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H16O3

[ Molecular Weight ]:
244.286

[ Flash Point ]:
166.0±22.5 °C

[ Exact Mass ]:
244.109940

[ PSA ]:
39.44000

[ LogP ]:
3.87

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.557

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds