Matairesinol

Names

[ CAS No. ]:
580-72-3

[ Name ]:
Matairesinol

[Synonym ]:
(3R,4R)-3,4-Bis(4-hydroxy-3-methoxybenzyl)dihydrofuran-2(3H)-one
Matairesinol
Matairesil
(-)-matairesinol
(3R,4R)-3,4-Bis(4-hydroxy-3-methoxybenzyl)dihydro-2(3H)-furanone
2(3H)-Furanone, dihydro-3,4-bis[(4-hydroxy-3-methoxyphenyl)methyl]-, (3R,4R)-
T5OVTJ C1R DQ CO1& D1R DQ CO1 &&(3R,4R)- Form

Biological Activity

[Description]:

Matairesinol confers anti-allergic effects in an allergic dermatitis mouse model. DfE-induced changes in IL-4 and IFN-γ mRNA expression in the ears of NC/Nga mice were reversed by matairesinol application[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[Target]

Human Endogenous Metabolite

[References]

[1]. Sung YY, Lee AY, Kim HK. Forsythia suspensa fruit extracts and the constituent matairesinol confer anti-allergic effects in an allergic dermatitis mouse model. J Ethnopharmacol. 2016;187:49-56.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
593.0±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₂O₆

[ Molecular Weight ]:
358.39

[ Flash Point ]:
212.3±22.2 °C

[ Exact Mass ]:
358.141632

[ PSA ]:
85.22000

[ LogP ]:
1.70

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.605

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Articles

Optimum yields of dibenzylbutyrolactone-type lignans from Cynareae fruits, during their ripening, germination and enzymatic hydrolysis processes, determined by on-line chromatographic methods.

Phytochem. Anal. 23(6) , 598-603, (2012)

Dibenzylbutyrolactone-type lignans are the physiologically active constituents of the achene fruits of Cynareae. These lignans occur in glycoside/aglycone forms: in the highest quantity of the arctiin...

Lignans inhibit cell growth via regulation of Wnt/beta-catenin signaling.

Food Chem. Toxicol. 48(8-9) , 2247-52, (2010)

As aberrant activation of Wnt/beta-catenin signaling is one of the major mechanisms of carcinogenesis in colon cancer, identification of inhibitors of this pathway may aid in colon cancer prevention. ...

Cytotoxic and HIF-1alpha inhibitory compounds from Crossosoma bigelovii.

J. Nat. Prod. 72(5) , 805-12, (2009)

Cytotoxicity-guided fractionation of an organic solvent extract of the plant Crossosoma bigelovii led to the discovery of a new strophanthidin glycoside (1) and two new 2-methylchromone glycosides (2 ...

Related Compounds

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