NCGC00071837

Names

[ Name ]:
NCGC00071837

[Synonym ]:
6-(3,4-Dimethoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
7H-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazine, 6-(3,4-dimethoxyphenyl)-3-(2-methoxyphenyl)-

Biological Activity

[Description]:

NCGC00071837 (PDE4-IN-5A) is a potent, selective PDE4 inhibitor with IC50 of 24 and 18 nM for PDE4A and PDE4D, respectively, weak inhibition for PDE4B (IC50=0.54 uM) and inactive for PDE1/3/5/7/9/10/11; directly stimulates (in the absence of NKH 477) and potentiates (in the presence of NKH 477) cAMP production.

[References]

References 1. Xia M, et al. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2412-7. 2. Skoumbourdis AP, et al. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1297-303. View Related Products by Target Phosphodiesterase (PDE)

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
596.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₈N₄O₃S

[ Molecular Weight ]:
382.436

[ Flash Point ]:
314.3±32.9 °C

[ Exact Mass ]:
382.109955

[ LogP ]:
3.34

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.667

Related Compounds

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