578747-98-5
578747-98-5 structure
- Name: NCGC00071837
- Chemical Name: 6-(3,4-Dimethoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
- CAS Number: 578747-98-5
- Molecular Formula: C19H18N4O3S
- Molecular Weight: 382.436
- Create Date: 2020-01-11 12:20:54
- Modify Date: 2024-01-09 14:45:42
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NCGC00071837 (PDE4-IN-5A) is a potent, selective PDE4 inhibitor with IC50 of 24 and 18 nM for PDE4A and PDE4D, respectively, weak inhibition for PDE4B (IC50=0.54 uM) and inactive for PDE1/3/5/7/9/10/11; directly stimulates (in the absence of NKH 477) and potentiates (in the presence of NKH 477) cAMP production.
| Name | 6-(3,4-Dimethoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine |
|---|---|
| Synonyms |
6-(3,4-Dimethoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
7H-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazine, 6-(3,4-dimethoxyphenyl)-3-(2-methoxyphenyl)- |
| Description | NCGC00071837 (PDE4-IN-5A) is a potent, selective PDE4 inhibitor with IC50 of 24 and 18 nM for PDE4A and PDE4D, respectively, weak inhibition for PDE4B (IC50=0.54 uM) and inactive for PDE1/3/5/7/9/10/11; directly stimulates (in the absence of NKH 477) and potentiates (in the presence of NKH 477) cAMP production. |
|---|---|
| References | References 1. Xia M, et al. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2412-7. 2. Skoumbourdis AP, et al. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1297-303. View Related Products by Target Phosphodiesterase (PDE) |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 596.1±60.0 °C at 760 mmHg |
| Molecular Formula | C19H18N4O3S |
| Molecular Weight | 382.436 |
| Flash Point | 314.3±32.9 °C |
| Exact Mass | 382.109955 |
| LogP | 3.34 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.667 |