8-Aminoquinoline
Names
[ CAS No. ]:
578-66-5
[ Name ]:
8-Aminoquinoline
[Synonym ]:
8-Quinolinamine
MFCD00006809
quinolin-8-amine
EINECS 209-427-9
8-Aminoquinoline
Biological Activity
[Description]:
[Related Catalog]:
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
289.8±0.0 °C at 760 mmHg
[ Melting Point ]:
62-65ºC
[ Molecular Formula ]:
C9H8N2
[ Molecular Weight ]:
144.17
[ Flash Point ]:
171.5±8.1 °C
[ Exact Mass ]:
144.068741
[ PSA ]:
38.91000
[ LogP ]:
1.88
[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C
[ Index of Refraction ]:
1.708
[ Water Solubility ]:
slightly soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VA9627000
- CHEMICAL NAME :
- Quinoline, 8-amino-
- CAS REGISTRY NUMBER :
- 578-66-5
- BEILSTEIN REFERENCE NO. :
- 0114474
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C9-H8-N2
- MOLECULAR WEIGHT :
- 144.19
- WISWESSER LINE NOTATION :
- T66 BNJ JQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 480 mg/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - other effects
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Human Leukocyte
- DOSE/DURATION :
- 100 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 39,285,1977
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319
[ Precautionary Statements ]:
P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R20/21/22;R36/37/38;R68
[ Safety Phrases ]:
S22-S26-S36/37/39
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
VA9627000
[ HS Code ]:
29334990
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933499090
[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Malaria Journal 11 , 259, (2012)
The 8-aminoquinoline (8AQ) drug primaquine (PQ) is currently the only approved drug effective against the persistent liver stage of the hypnozoite forming strains Plasmodium vivax and Plasmodium ovale...
Aminoquinolines as fluorescent labels for hydrophilic interaction liquid chromatography of oligosaccharides.Biol. Chem. 393(8) , 757-65, (2012)
In this study, we investigated the potential of four different aminoquinoline (AQ) compounds as fluorescent labels for glycan analysis using hydrophilic interaction liquid chromatography (HILIC) and f...
Copper chelator induced efficient episodic memory recovery in a non-transgenic Alzheimer's mouse model.PLoS ONE 7(8) , e43105, (2012)
Alzheimer's disease (AD) is a neurodegenerative syndrom involving many different biological parameters, including the accumulation of copper metal ions in Aβ amyloid peptides due to a perturbation of ...