1,1'-[(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate]-b-D-Glucopyranose

Names

[ Name ]:
1,1'-[(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate]-b-D-Glucopyranose

[Synonym ]:
Dicrocin
(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl (3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate

Biological Activity

[Description]:

Crocin IV (Dicrocin), a crocetin glycoside, is a carotenoid pigment. Crocin IV has potent antioxidant activity[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Crocin IV (Dicrocin; 10 μM; 24 hours) has little or no effect on the prolongation of cell survival in PC12 cell[1]. Crocin IV enhances γ-GCS mRNA expression in serum-deprived and hypoxic PC12 cells[1]. Measurements of cell viability, peroxidized membrane lipids and caspase-3 activity showed that the rank order of the neuroprotective potency at a concentration of 10 μM is crocin>tricrocin>dicrocin and picrocrocin (the latter two crocins had a little or no potency)[1].

[References]

[1]. Takashi Ochiai, et al. Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo. Biochim Biophys Acta. 2007 Apr;1770(4):578-84.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
879.8±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₂H₄₄O₁₄

[ Molecular Weight ]:
652.683

[ Flash Point ]:
275.6±27.8 °C

[ Exact Mass ]:
652.273132

[ LogP ]:
3.98

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.618

Related Compounds

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