Antibiotic C 9154

Names

[ Name ]:
Antibiotic C 9154

[Synonym ]:
Fumaramidmycin
Antibiotic C 9154

Biological Activity

[Description]:

Fumaramidmycin is an antibiotic found in Streptomyces kurssanovii NR-7GG1. Fumaramidmycin shows an antimicrobial activity against both Gram-positive and Gram-negative bacteria[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. H B Maruyama, et al. A new antibiotic, fumaramidmycin I. Production, biological properties and characterization of producer strain. J Antibiot (Tokyo). 1975 Sep;28(9):636-47.

Chemical & Physical Properties

[ Density]:
1.25g/cm3

[ Boiling Point ]:
510.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₂N₂O₃

[ Molecular Weight ]:
232.23500

[ Flash Point ]:
262.7ºC

[ Exact Mass ]:
232.08500

[ PSA ]:
89.26000

[ LogP ]:
1.00460

[ Index of Refraction ]:
1.577

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EM4300000

CHEMICAL NAME :: 2-Butenediamide, N-(phenylacetyl)-, (E)-

CAS REGISTRY NUMBER :: 57687-92-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H12-N2-O3

MOLECULAR WEIGHT :: 232.26

WISWESSER LINE NOTATION :: ZV1U1VMV1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 28,636,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,759,1978

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds

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