Bromo-PEG4-bromide

Names

[ Name ]:
Bromo-PEG4-bromide

[Synonym ]:
3,6,9,12-Tetraoxatetradecane, 1,14-dibromo-
1,14-Dibromo-3,6,9,12-tetraoxatetradecane
1,2-bis[2-(2-bromoethoxy)ethoxy]ethane

Biological Activity

[Description]:

Bromo-PEG4-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Mulyana Y, et al. Oligonuclear polypyridylruthenium(II) complexes incorporating flexible polar and non-polar bridges: synthesis, DNA-binding and cytotoxicity. Dalton Trans. 2011 Feb 21;40(7):1510-23.

[2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
373.2±32.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₂₀Br₂O₄

[ Molecular Weight ]:
364.071

[ Flash Point ]:
152.9±23.6 °C

[ Exact Mass ]:
361.972809

[ PSA ]:
36.92000

[ LogP ]:
0.80

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.489

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2909199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909199090

[ Summary ]:
2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%