DQn-1

Names

[ Name ]:
DQn-1

Biological Activity

[Description]:

DQn-1 is a potent antifolate with activity against Mycobacterium tuberculosis (Mtb) (MIC90=0.03 µM). DQn-1 directly inhibits DHFR enzyme activity, with IC50s of 8.7 and 7.6 nM for Mtb and human DHFR enzyme, respectively[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

DQn-1 抑制 Mycobacterium tuberculosis，MIC90 值分别为 0.03 µM 和 1 µM[1]。

[In Vivo]

DQn-1 (5-10 mg/kg; p.o. for 8 days) 未能检测到小鼠 Mtb 负荷有任何显着降低[1]。

[References]

[1]. Kumar A, et, al. A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis. ACS Infect Dis. 2015 Dec 11;1(12):604-14.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₄ClN₅O₂

[ Molecular Weight ]:
343.77

[ Exact Mass ]:
343.08400

[ PSA ]:
128.61000

[ LogP ]:
2.69110

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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