Pamidronate disodium

Names

[ Name ]:
Pamidronate disodium

[Synonym ]:
Disodium (3-amino-1-hydroxypropane-1,1-diyl)bis[hydrogen (phosphonate)]
Pamidronate disodium salt
Pamidronate disodium
Phosphonic acid, (3-amino-1-hydroxypropylidene)bis-, sodium salt (1:2)
Dinatrium-(3-amino-1-hydroxypropan-1,1-diyl)bis[hydrogen-(phosphonat)]
APD
Disodium (3-amino-1-hydroxy-1-phosphonopropyl)phosphonate
MFCD01938386
EINECS 260-647-1
(3-amino-1-hydroxypropane-1,1-diyl)bis[hydrogène (phosphonate)] de disodium
Pamidronate (Disodium)

Biological Activity

[Description]:

Pamidronate disodium, a bisphosphonate drug, can help to strengthen bones.Target: OthersPamidronate belongs to the family of medications known as bisphosphonates. It is used to treat hypercalcemia (high blood calcium) by people who have cancer. Pamidronate is also used to treat cancer that has spread to bones (bone metastases) due to different types of tumours and multiple myeloma (cancer of the bone marrow). Pamidronate is also used to treat the symptoms of Paget's disease of bone.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Zarychanski, R., et al., Osteonecrosis of the jaw associated with pamidronate therapy. Am J Hematol, 2006. 81(1): p. 73-5.

[Related Small Molecules]

Chemical & Physical Properties

[ Melting Point ]:
300 °C

[ Molecular Formula ]:
C₃H₁₁NNa₂O₇P₂

[ Molecular Weight ]:
281.05

[ PSA ]:
186.59000

[ Appearance of Characters ]:
solid | white

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: 28 mg/mL

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SZ6525000

CHEMICAL NAME :: Phosphonic acid, (3-amino-1-hydroxypropylidene)bis-, disodium salt

CAS REGISTRY NUMBER :: 57248-88-1

LAST UPDATED :: 199709

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C3-H9-N-O7-P2.2Na

MOLECULAR WEIGHT :: 279.05

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 750 ug/kg/5D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - visual field changes Sense Organs and Special Senses (Eye) - diplopia Sense Organs and Special Senses (Eye) - effect, not otherwise specified

REFERENCE :: ANZJB8 Australian and New Zealand Journal of Medicine. (Modern Medicine of Australia Pty., Ltd., 100 Pacific Highway, North Sydney, 2060, Australia) V.1- 1971- Volume(issue)/page/year: 24,320,1994

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 600 ug/kg/6H-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - changes in calcium

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,622,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 900 ug/kg

TOXIC EFFECTS :: Musculoskeletal - joints

REFERENCE :: APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992- Volume(issue)/page/year: 31,499,1997 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1740 mg/kg

SEX/DURATION :: female 15-22 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,654,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 60 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,654,1992

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R22:Harmful if swallowed. R48:Danger of serious damage to health by prolonged exposure. R41:Risk of serious damage to eyes. R37/38:Irritating to respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .

[ Safety Phrases ]:
S22:Do not breathe dust . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S45:In case of accident or if you feel unwell, seek m

[ WGK Germany ]:
3

[ RTECS ]:
SZ6525000

[ HS Code ]:
2931900090

Customs

[ HS Code ]: 2931900090

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%